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We could simply review the basic controls in a vacuum, but that s not very interesting. Instead, in this section you ll create a meaningful business application using the ASP.NET and AJAX controls in context. The application will be for a fictitious company called AdventureWorks, a recreational equipment retailer. You may remember the name AdventureWorks from 1; it s the name of the fictional company used in the sample databases you downloaded and installed there. You won t need the databases now, but you ll see them again in 4. To begin, create a new web site using the ASP.NET AJAX-Enabled Web Application template (similar to what you did in the previous chapter). Name your new project AdventureWorks. For this version of the program, you ll use hardcoded data. In later chapters you will add dynamic content with data retrieved from a database. The first page you re going to build is the order form. The finished page will look something like Figure 2-9, where all the types of controls are labeled. This somewhat contrived web page (see the sidebar Good Sites Look Good ) is intended to demonstrate many of the available ASP.NET controls for various applications.

xview( moveto , FRACTION) yview( moveto , FRACTION)

xview( scroll , NUMBER, WHAT) yview( scroll , NUMBER, WHAT)

Table 17-13

DNA POLYMERASE I II III 3 5 EXONUCLEASE (PROOFREADING) Yes Yes Yes No No Yes Yes Yes 5 3 EXONUCLEASE (EXCISION) Yes No No No No No No No

Moves the scrollbar to the location specified by fraction; the new value will indicate the leftmost, or topmost, character or pixel of the scrollbar tab Note that the first argument is a constant Indicates that the view should be moved up or down, or left or right, for NUMBER increments If WHAT is units, then it is scrolled according to the increment in the xscrollincrement and yscrollincrement properties If WHAT is pages, then the widget is scrolled NUMBER pages

17:

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ROLE Gap repair RNA primer removal Repair Replication Nuclear replication Continuous (lagging) strand synthesis Nuclear repair Mitochondrial replication Nuclear replication Continuous (leading) strand replication Nuclear repair

Figure 17-1

The supported properties and methods are shown in Table 17-14 Here s the script that generated Figure 17-1 It provides a simple tool for converting feet into meters and vice versa

use Tk; my ($feetscale, $metrescale) = (0,0); $main = MainWindow->new(); $feetframe = $main->Frame()->pack(side => 'left');

Recombination rearranges genetic information by breaking and joining DNA Homologous: Two DNA sequences that are very similar or identical Homologous recombination occurs between two genes that have very similar or identical sequences Nonhomologous: Two DNA sequences that are very different Nonhomologous recombination can occur between two unrelated genes Aligned: Recombination occurs between the same genes and at the same location within each gene Gene order is not altered Nonaligned: Recombination occurs between two different genes The order of genes is altered by nonaligned recombination

$feetframe->Scale(command variable width length orient from to resolution tickinterval label )->pack(side

|

\&update_feet, \$feetscale, 20, 400, 'vertical', 0, 328, 1, 25, 'Feet' 'top');

There are lots of ways of moving genetic information around All contribute to genetic diversity in the population The result of recombination can be pictured as breaking two DNA strands into two pieces, swapping the ends, and rejoining At the level of the individual strands, it s a little more complicated, but for our purposes it s good enough Recombination can occur in regions of sequence homology If these homologous regions correspond to the same position in the same gene, this is an aligned recombination (also called recombination with equal crossing over ) If all the genes on the two chromosomes are the same, then recombination won t have any affect But if one of the genes contains a mutation, recombination results in two new chromosomal structures in which different genes are linked to the site of the mutation Note that in recombination between two chromosomes, no information is actually lost all the DNA ends up somewhere However, each offspring receives only one of the two new chromosomes (Fig 5-3) If recombination occurs between two regions of homology that are in different genes (unaligned recombination or unequal crossing over), individual genes can be duplicated or lost in the resulting daughter DNA A good example is the globin gene family There are several - and globin genes that share some sequence homology If recombination occurs between two similar (but not identical) genes, the resulting DNA will have been rearranged so that one progeny is a gene or two short while the other offspring has a few too many Again, no DNA has actually been lost; it s just been redistributed between offspring (Fig 5-4) Gene deletion may cause genetic disease if the gene product is essential, and gene duplication, which creates an extra copy of the gene, can

$feetframe->Label(textvariable => \$feetscale)->pack(side => 'top', pady => 5); $metreframe = $main->Frame()->pack(side => 'left'); $metreframe->Scale(command variable width length orient from to resolution tickinterval label )->pack(side => => => => => => => => => => => \&update_metre, \$metrescale, 20, 400, 'vertical', 0, 100, 1, 10, 'Metres' 'top');

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